Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes.
نویسندگان
چکیده
To enable studies to elucidate the detailed biological function of dysiherbaine and neodysiherbaine A, potent and subunit-selective agonists for ionotropic glutamate receptors, the derivative with a hydroxymethyl substituent at the C10 position has been developed. Preliminary biological evaluation of the analogue showed that a C10 hydroxymethyl substituent produced significant alterations in binding affinities for the ionotropic glutamate receptor subtypes.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 16 22 شماره
صفحات -
تاریخ انتشار 2006